Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

We have previously shown that overexpressing subunits of the iron-binding protein ferritin can rescue the toxicity of the amyloid β (Aβ) peptide in our Drosophila model system. These data point to an important pathogenic role for iron in Alzheimer disease. In this study, we have used an iron-selecti...

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Autores principales: Liu, Beinan, Moloney, Aileen, Meehan, Sarah, Morris, Kyle, Thomas, Sally E., Serpell, Louise C., Hider, Robert, Marciniak, Stefan J., Lomas, David A., Crowther, Damian C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039358/
https://ncbi.nlm.nih.gov/pubmed/21147772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.158980
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