Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

The pharmacologic utility of lengthy peptides can be hindered by loss of bioactive structure and rapid proteolysis, which limits bioavailability. For example, enfuvirtide (Fuzeon, T20, DP178), a 36-amino acid peptide that inhibits human immunodeficiency virus type 1 (HIV-1) infection by effectively...

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Detalles Bibliográficos
Autores principales: Bird, Gregory H., Madani, Navid, Perry, Alisa F., Princiotto, Amy M., Supko, Jeffrey G., He, Xiaoying, Gavathiotis, Evripidis, Sodroski, Joseph G., Walensky, Loren D.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922607/
https://ncbi.nlm.nih.gov/pubmed/20660316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002713107
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