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Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
The pharmacologic utility of lengthy peptides can be hindered by loss of bioactive structure and rapid proteolysis, which limits bioavailability. For example, enfuvirtide (Fuzeon, T20, DP178), a 36-amino acid peptide that inhibits human immunodeficiency virus type 1 (HIV-1) infection by effectively...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922607/ https://ncbi.nlm.nih.gov/pubmed/20660316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002713107 |
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