Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

The pharmacologic utility of lengthy peptides can be hindered by loss of bioactive structure and rapid proteolysis, which limits bioavailability. For example, enfuvirtide (Fuzeon, T20, DP178), a 36-amino acid peptide that inhibits human immunodeficiency virus type 1 (HIV-1) infection by effectively...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bird, Gregory H., Madani, Navid, Perry, Alisa F., Princiotto, Amy M., Supko, Jeffrey G., He, Xiaoying, Gavathiotis, Evripidis, Sodroski, Joseph G., Walensky, Loren D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922607/
https://ncbi.nlm.nih.gov/pubmed/20660316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002713107
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg