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Ago-TNRC6 complex triggers microRNA-mediated mRNA decay by promoting biphasic deadenylation followed by decapping
MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly through promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA-tethering, over-expressi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921184/ https://ncbi.nlm.nih.gov/pubmed/19838187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1709 |
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