Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway

Nonsense-mediated mRNA decay (NMD) is an RNA surveillance pathway that detects and destroys aberrant mRNAs containing nonsense or premature termination codons (PTCs) in a translation-dependent manner in eukaryotes. In yeast, the NMD pathway bypasses the deadenylation step and directly targets PTC-co...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Chen, Chyi-Ying A., Shyu, Ann-Bin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162215/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832468/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4805-4813.2003
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