Asparagine starvation suppresses histone demethylation through iron depletion

Summary: Intracellular α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the histone demethylation reactions. Since α-ketoglutarate is an intermediate of the tricarboxylic acid cycle and a product of transamination, its availabilit...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Jie Jiang, Sankalp Srivastava, Sheng Liu, Gretchen Seim, Rodney Claude, Minghua Zhong, Sha Cao, Utpal Davé, Reuben Kapur, Amber L. Mosley, Chi Zhang, Jun Wan, Jing Fan, Ji Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-04-01
Serija:	iScience
Teme:	Biological sciences Physiology Molecular biology Molecular mechanism of gene regulation Epigenetics
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2589004223005023
Oznake:	Označite Brez oznak, prvi označite!