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Asparagine starvation suppresses histone demethylation through iron depletion

Summary: Intracellular α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the histone demethylation reactions. Since α-ketoglutarate is an intermediate of the tricarboxylic acid cycle and a product of transamination, its availabilit...

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Principais autores: Jie Jiang, Sankalp Srivastava, Sheng Liu, Gretchen Seim, Rodney Claude, Minghua Zhong, Sha Cao, Utpal Davé, Reuben Kapur, Amber L. Mosley, Chi Zhang, Jun Wan, Jing Fan, Ji Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-04-01
Colecção:iScience
Assuntos:
Biological sciences
Physiology
Molecular biology
Molecular mechanism of gene regulation
Epigenetics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589004223005023
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