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Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes
Zinc finger nucleases (ZFNs) are custom-designed molecular scissors, engineered to cut at specific DNA sequences. ZFNs combine the zinc finger proteins (ZFPs) with the nonspecific cleavage domain of the FokI restriction enzyme. The DNA-binding specificity of ZFNs can be easily altered experimentally...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921164/ https://ncbi.nlm.nih.gov/pubmed/19488728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-59745-483-4_40 |
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