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TAp63 induces senescence and suppresses tumorigenesis in vivo

p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an issue complicated by the existence of two classes of p63 isoforms1. Here we show that TAp63 isoforms are robust mediators of senescence that inhibit tumorigenesis in vivo. Whereas gain of TAp63 induce...

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Autors principals: Guo, Xuecui, Keyes, William M., Papazoglu, Cristian, Zuber, Johannes, Li, Wangzhi, Lowe, Scott W., Vogel, Hannes, Mills, Alea A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920298/
https://ncbi.nlm.nih.gov/pubmed/19898465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1988
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