ΔNp63α is an oncogene that induces Lsh expression and promotes stem-like proliferation

The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor suppressive mechanism of cellular senescence, causing a striking absence of stratified epithelia such as the skin. Here we identify the predominant p63 isoform, Δ...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Keyes, William M., Pecoraro, Matteo, Aranda, Victoria, Vernersson-Lindahl, Emma, Li, Wangzhi, Vogel, Hannes, Guo, Xuecui, Garcia, Elvin L., Michurina, Tatyana V., Enikolopov, Grigori, Muthuswamy, Senthil K., Mills, Alea A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373450/
https://ncbi.nlm.nih.gov/pubmed/21295273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.12.009
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