ΔNp63α is an oncogene that induces Lsh expression and promotes stem-like proliferation

The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor suppressive mechanism of cellular senescence, causing a striking absence of stratified epithelia such as the skin. Here we identify the predominant p63 isoform, Δ...

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Publié dans:Cell Stem Cell
Auteurs principaux: Keyes, William M., Pecoraro, Matteo, Aranda, Victoria, Vernersson-Lindahl, Emma, Li, Wangzhi, Vogel, Hannes, Guo, Xuecui, Garcia, Elvin L., Michurina, Tatyana V., Enikolopov, Grigori, Muthuswamy, Senthil K., Mills, Alea A.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373450/
https://ncbi.nlm.nih.gov/pubmed/21295273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.12.009
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