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ΔNp63α is an oncogene that induces Lsh expression and promotes stem-like proliferation
The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor suppressive mechanism of cellular senescence, causing a striking absence of stratified epithelia such as the skin. Here we identify the predominant p63 isoform, Δ...
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| Veröffentlicht in: | Cell Stem Cell |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4373450/ https://ncbi.nlm.nih.gov/pubmed/21295273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.12.009 |
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