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p63 deficiency activates a program of cellular senescence and leads to accelerated aging
The p53 tumor suppressor plays a key role in organismal aging. A cellular mechanism postulated to drive the aging process is cellular senescence, mediated in part by p53. Although senescent cells accumulate in elderly individuals, most studies have relied on correlating in vitro senescence assays wi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1199570/ https://ncbi.nlm.nih.gov/pubmed/16107615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.342305 |
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