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p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors

Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/− mice in both WT and p53-c...

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Main Authors: Keyes, William M., Vogel, Hannes, Koster, Maranke I., Guo, Xuecui, Qi, Yi, Petherbridge, Kristin M., Roop, Dennis R., Bradley, Allan, Mills, Alea A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482510/
https://ncbi.nlm.nih.gov/pubmed/16714381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602477103
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