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FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most FA...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897475/ https://ncbi.nlm.nih.gov/pubmed/23806336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.017 |
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