ERBB2 regulation by Estrogen Receptor-Pax2 determines tamoxifen response

Cross talk between the Estrogen Receptor (ER) and ErbB2/HER-2 pathways have long been implicated in breast cancer aetiology and drug response1, yet no direct connection at a transcriptional level has been shown. We now show that estrogen-ER and tamoxifen-ER complexes directly repress ErbB2 transcrip...

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Detalhes bibliográficos
Main Authors: Hurtado, Antoni, Holmes, Kelly A., Geistlinger, Timothy R., Hutcheson, Iain R., Nicholson, Robert I., Brown, Myles, Jiang, Jie, Howat, William J., Ali, Simak, Carroll, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920208/
https://ncbi.nlm.nih.gov/pubmed/19005469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07483
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