The proapoptotic gene interferon regulatory factor-1 mediates the antiproliferative outcome of paired box 2 gene and tamoxifen

Tamoxifen is the most prescribed selective estrogen receptor (ER) modulator in patients with ER-positive breast cancers. Tamoxifen requires the transcription factor paired box 2 protein (PAX2) to repress the transcription of ERBB2/HER2. Now, we identified that PAX2 inhibits cell growth of ER+/HER2−...

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Pubblicato in:Oncogene
Autori principali: Wang, Shixiong, Somisetty, Venkata S., Bai, Baoyan, Chernukhin, Igor, Niskanen, Henri, Kaikkonen, Minna U., Bellet, Meritxell, Carroll, Jason S., Hurtado, Antoni
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529584/
https://ncbi.nlm.nih.gov/pubmed/32843722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01435-4
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