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fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models

OBJECTIVES: To elucidate the pharmacokinetic/pharmacodynamic (PK/PD) index that predicts colistin efficacy against Acinetobacter baumannii in neutropenic murine thigh and lung infection models, and to determine the extent of the emergence of resistance in vivo to colistin. METHODS: PK/PD of colistin...

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Bibliografske podrobnosti
Main Authors: Dudhani, Rajesh V., Turnidge, John D., Nation, Roger L., Li, Jian
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920176/
https://ncbi.nlm.nih.gov/pubmed/20573659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq226
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