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Activity of Colistin against Heteroresistant Acinetobacter baumannii and Emergence of Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Three clinically relevant intermittent regimens, and a continuous infusion, of colistin were simulated in an in vitro pharmacokinetic/pharmacodynamic model against two colistin-heteroresistant strains of Acinetobacter baumannii. Extensive initial killing was followed by regrowth as early as 6 h late...

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Detalhes bibliográficos
Main Authors: Tan, Chun-Hong, Li, Jian, Nation, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043182/
https://ncbi.nlm.nih.gov/pubmed/17620384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01571-06
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