Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model

The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Lin, Yu-Wei, Zhou, Qi Tony, Han, Mei-Ling, Chen, Ke, Onufrak, Nikolas J., Wang, Jiping, Turnidge, John D., Howden, Benjamin P., Forrest, Alan, Chan, Hak-Kim, Li, Jian
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786800/
https://ncbi.nlm.nih.gov/pubmed/29229637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01790-17
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