Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model

Optimized dosage regimens of aerosolized colistin (as colistin methanesulfonate [CMS]) are urgently required to maximize bacterial killing against multidrug-resistant Gram-negative bacteria while minimizing toxicity. This study aimed to develop a mechanism-based pharmacokinetic (PK)/pharmacodynamic...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Lin, Yu-Wei, Zhou, Qi Tony, Han, Mei-Ling, Onufrak, Nikolas J., Chen, Ke, Wang, Jiping, Forrest, Alan, Chan, Hak-Kim, Li, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826166/
https://ncbi.nlm.nih.gov/pubmed/29263069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01965-17
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky