Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic-Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model

Pulmonary administration of polymyxins is increasingly used for the treatment of respiratory tract infections caused by multidrug-resistant Gram-negative bacteria, such as those in patients with cystic fibrosis. However, there is a lack of pharmacokinetics (PK), pharmacodynamics (PD), and toxicity d...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Lin, Yu-Wei, Zhou, Qi, Onufrak, Nikolas J., Wirth, Veronika, Chen, Ke, Wang, Jiping, Forrest, Alan, Chan, Hak-Kim, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527630/
https://ncbi.nlm.nih.gov/pubmed/28559256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00211-17
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