Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model

Optimized dosage regimens of aerosolized colistin (as colistin methanesulfonate [CMS]) are urgently required to maximize bacterial killing against multidrug-resistant Gram-negative bacteria while minimizing toxicity. This study aimed to develop a mechanism-based pharmacokinetic (PK)/pharmacodynamic...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Lin, Yu-Wei, Zhou, Qi Tony, Han, Mei-Ling, Onufrak, Nikolas J., Chen, Ke, Wang, Jiping, Forrest, Alan, Chan, Hak-Kim, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826166/
https://ncbi.nlm.nih.gov/pubmed/29263069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01965-17
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