BMS-690514, a VEGFR and EGFR tyrosine kinase inhibitor, shows anti-tumoural activity on non-small-cell lung cancer xenografts and induces sequence-dependent synergistic effect with radiation

BACKGROUND: Non-small-cell lung cancer (NSCLC) is an aggressive disease in which vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) are implicated in tumour growth, tumour resistance to radiation and chemotherapy, and disease relapse. We have investigated the anti-tumoural e...

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Detalhes bibliográficos
Main Authors: Loriot, Y, Mordant, P, Dorvault, N, De la motte Rouge, T, Bourhis, J, Soria, J-C, Deutsch, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920012/
https://ncbi.nlm.nih.gov/pubmed/20628392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605748
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