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BMS-690514, a VEGFR and EGFR tyrosine kinase inhibitor, shows anti-tumoural activity on non-small-cell lung cancer xenografts and induces sequence-dependent synergistic effect with radiation

BACKGROUND: Non-small-cell lung cancer (NSCLC) is an aggressive disease in which vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) are implicated in tumour growth, tumour resistance to radiation and chemotherapy, and disease relapse. We have investigated the anti-tumoural e...

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Bibliografiske detaljer
Main Authors: Loriot, Y, Mordant, P, Dorvault, N, De la motte Rouge, T, Bourhis, J, Soria, J-C, Deutsch, E
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920012/
https://ncbi.nlm.nih.gov/pubmed/20628392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605748
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