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Residues 190–210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
DNA-topoisomerase I (topo I) unwinds the DNA- double helix by cutting one strand and allowing rotation of the other. In vitro, this function does not require the N-terminal domain of the enzyme, which is believed to regulate cellular properties. To assess this role, we studied the cellular distribut...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291868/ https://ncbi.nlm.nih.gov/pubmed/14654701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg927 |
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