Cell Cycle–coupled Relocation of Types I and II Topoisomerases and Modulation of Catalytic Enzyme Activities

We visualized DNA topoisomerases in A431 cells and isolated chromosomes by isoenzyme-selective immunofluorescence microscopy. In interphase, topoisomerase I mainly had a homogeneous nuclear distribution. 10–15% of the cells exhibited granular patterns, 30% showed bright intranucleolar patches. Topoi...

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Main Authors: Meyer, Kay N., Kjeldsen, Eigil, Straub, Tobias, Knudsen, Birgitta R., Hickson, Ian D., Kikuchi, Akihiko, Kreipe, Hans, Boege, Fritz
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2132491/
https://ncbi.nlm.nih.gov/pubmed/9049244
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