Decreased Camptothecin Sensitivity of the Stem-Cell-Like Fraction of Caco2 Cells Correlates with an Altered Phosphorylation Pattern of Topoisomerase I

The CD44+ and CD44− subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44− cells. The relative resistance of CD44+ cells was correlated with (i) reduced ac...

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Hlavní autoři: Roy, Amit, Tesauro, Cinzia, Frøhlich, Rikke, Hede, Marianne S., Nielsen, Maria J., Kjeldsen, Eigil, Bonven, Bjarne, Stougaard, Magnus, Gromova, Irina, Knudsen, Birgitta R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069021/
https://ncbi.nlm.nih.gov/pubmed/24960044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099628
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