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A Novel Pharmacophore Model for the Design of Anthrax Lethal Factor Inhibitors
This study aims at the identification of novel structural features on the surface of the Zn-dependant metalloprotease Lethal Factor (LF) from Anthrax onto which to design novel and selective inhibitors. We report that by targeting an unexplored region of LF that exhibits ligand-induced conformationa...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918674/ https://ncbi.nlm.nih.gov/pubmed/20572812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.01000.x |
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