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Structure Activity Relationship Studies of a Novel Series of Anthrax Lethal Factor Inhibitors

We report on the identification of a novel small molecule inhibitor of anthrax lethal factor using a high-throughput screening approach. Guided by molecular docking studies, we carried out structure activity relationship (SAR) studies and evaluated activity and selectivity of most promising compound...

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Bibliografiske detaljer
Main Authors: Johnson, Sherida L., Chen, Li-Hsing, Barille, Elisa, Emdadi, Aras, Sabet, Mojgan, Yuan, Hongbin, Wei, Jun, Guiney, Donald, Pellecchia, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730741/
https://ncbi.nlm.nih.gov/pubmed/19359184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.040
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