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A High-throughput Screening Approach to Anthrax Lethal Factor Inhibition
A high-throughput screening approach was used to identify new inhibitors of the metallo-protease lethal factor from Bacillus anthracis. A library of ~14,000 compounds was screened using a fluorescence-based in vitro assay and hits were further characterized enzymatically via measurements of IC(50) a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2020844/ https://ncbi.nlm.nih.gov/pubmed/17320146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2006.12.005 |
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