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Anthrax Lethal Factor Protease Inhibitors: Synthesis, SAR and Structure-Based 3D QSAR Studies

We have recently identified a series of compounds which efficiently inhibit Anthrax lethal factor (LF) metallo-protease. Here we present further structure activity relationship and CoMFA (Comparative Molecular Field Analysis) studies on newly derived inhibitors. The obtained 3D QSAR model was subseq...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Johnson, Sherida L., Jung, Dawoon, Forino, Martino, Chen, Ya, Satterthwait, Arnold, Rozanov, Dmitry V., Strongin, Alex Y., Pellecchia, Maurizio
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2006
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164827/
https://ncbi.nlm.nih.gov/pubmed/16392787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050892j
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