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MHC-I restricted Melanoma Antigen Specific TCR Engineered Human CD4(+) T Cells Exhibit Multifunctional Effector and Helper Responses, In Vitro
MHC class 1-restricted human melanoma epitope MART-1(27–35) specific TCR engineered CD4+CD25− T cells synthesize Th1 type cytokines and exhibit cytolytic effector function upon cognate stimulation. A detailed characterization of such TCR-engineered CD4+CD25− T cells now reveals that they are multifu...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917536/ https://ncbi.nlm.nih.gov/pubmed/20547105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.04.013 |
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