MHC-I restricted Melanoma Antigen Specific TCR Engineered Human CD4(+) T Cells Exhibit Multifunctional Effector and Helper Responses, In Vitro

MHC class 1-restricted human melanoma epitope MART-1(27–35) specific TCR engineered CD4+CD25− T cells synthesize Th1 type cytokines and exhibit cytolytic effector function upon cognate stimulation. A detailed characterization of such TCR-engineered CD4+CD25− T cells now reveals that they are multifu...

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Detalhes bibliográficos
Main Authors: Ray, Swagatam, Chhabra, Arvind, Chakraborty, Nitya G., Hegde, Upendra, Dorsky, David I., Chodon, Thinle, von Euw, Erika, Comin-Anduix, Begonya, Koya, Richard C., Ribas, Antoni, Economou, James S., Rosenberg, Steven A., Mukherji, Bijay
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917536/
https://ncbi.nlm.nih.gov/pubmed/20547105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.04.013
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