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CTLA4 blockade increases Th17 cells in patients with metastatic melanoma
BACKGROUND: Th17 cells are CD4+ cells that produce interleukin 17 (IL-17) and are potent inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in peripheral blood of patients treated with the anti-CTLA4 antibody tremelimumab since its major dose limiting toxic...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697137/ https://ncbi.nlm.nih.gov/pubmed/19457253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-35 |
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