Dendritic Cell Vaccination Combined with CTLA4 Blockade in Patients with Metastatic Melanoma

PURPOSE: Tumor antigen-loaded dendritic cells (DC) are believed to activate antitumor immunity by stimulating T cells, and cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-blocking antibodies should release a key negative regulatory pathway on T cells. The combination was tested in a phase 1 clin...

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Main Authors: Ribas, Antoni, Comin-Anduix, Begoña, Chmielowski, Bartosz, Jalil, Jason, de la Rocha, Pilar, McCannel, Tara A., Ochoa, Maria Teresa, Seja, Elizabeth, Villanueva, Arturo, Oseguera, Denise K., Straatsma, Bradley R., Cochran, Alistair J., Glaspy, John A., Hui, Liu, Marincola, Francesco M., Wang, Ena, Economou, James S., Gomez-Navarro, Jesus
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765061/
https://ncbi.nlm.nih.gov/pubmed/19789309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1254
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