CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans

BACKGROUND: CTLA4 blocking monoclonal antibodies provide durable clinical benefit in a subset of patients with advanced melanoma mediated by intratumoral lymphocytic infiltrates. A key question is defining if the intratumoral infiltration is a differentiating factor between patients with and without...

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Main Authors: Huang, Rong Rong, Jalil, Jason, Economou, James S., Chmielowski, Bartosz, Koya, Richard C., Mok, Stephen, Sazegar, Hooman, Seja, Elizabeth, Villanueva, Arturo, Gomez-Navarro, Jesus, Glaspy, John A., Cochran, Alistair J., Ribas, Antoni
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117971/
https://ncbi.nlm.nih.gov/pubmed/21558401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0407
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