CTLA4 blockade increases Th17 cells in patients with metastatic melanoma

BACKGROUND: Th17 cells are CD4+ cells that produce interleukin 17 (IL-17) and are potent inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in peripheral blood of patients treated with the anti-CTLA4 antibody tremelimumab since its major dose limiting toxic...

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Autores principales: von Euw, Erika, Chodon, Thinle, Attar, Narsis, Jalil, Jason, Koya, Richard C, Comin-Anduix, Begonya, Ribas, Antoni
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697137/
https://ncbi.nlm.nih.gov/pubmed/19457253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-35
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