Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

Obtaining suitable seed viruses for influenza vaccines poses a challenge for public health authorities and manufacturers. We used reverse genetics to generate vaccine seed-compatible viruses from the 2009 pandemic swine-origin influenza virus. Comparison of viruses recovered with variations in resid...

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Main Authors: Suphaphiphat, Pirada, Franti, Michael, Hekele, Armin, Lilja, Anders, Spencer, Terika, Settembre, Ethan, Palmer, Gene, Crotta, Stefania, Tuccino, Annunziata B, Keiner, Bjoern, Trusheim, Heidi, Balabanis, Kara, Sackal, Melissa, Rothfeder, Mithra, Mandl, Christian W, Dormitzer, Philip R, Mason, Peter W
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2010
נושאים:
Short Report
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914672/
https://ncbi.nlm.nih.gov/pubmed/20630098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-157
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