Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

Obtaining suitable seed viruses for influenza vaccines poses a challenge for public health authorities and manufacturers. We used reverse genetics to generate vaccine seed-compatible viruses from the 2009 pandemic swine-origin influenza virus. Comparison of viruses recovered with variations in resid...

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Autores principales: Suphaphiphat, Pirada, Franti, Michael, Hekele, Armin, Lilja, Anders, Spencer, Terika, Settembre, Ethan, Palmer, Gene, Crotta, Stefania, Tuccino, Annunziata B, Keiner, Bjoern, Trusheim, Heidi, Balabanis, Kara, Sackal, Melissa, Rothfeder, Mithra, Mandl, Christian W, Dormitzer, Philip R, Mason, Peter W
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914672/
https://ncbi.nlm.nih.gov/pubmed/20630098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-157
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