Cloning, Heterologous Expression, and Distinct Substrate Specificity of Protein Farnesyltransferase from Trypanosoma brucei

Protein prenylation occurs in the protozoan that causes African sleeping sickness (Trypanosoma brucei), and the protein farnesyltransferase appears to be a good target for developing drugs. We have cloned the α- and β-subunits of T. brucei protein farnesyltransferase (TB-PFT) using nucleic acid prob...

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Detaylı Bibliyografya
Asıl Yazarlar: Buckner, Frederick S., Yokoyama, Kohei, Nguyen, Lisa, Grewal, Anita, Erdjument-Bromage, Hediye, Tempst, Paul, Strickland, Corey L., Xiao, Li, Van Voorhis, Wesley C., Gelb, Michael H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2000
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913713/
https://ncbi.nlm.nih.gov/pubmed/10749864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M000975200
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