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Cloning, Heterologous Expression, and Distinct Substrate Specificity of Protein Farnesyltransferase from Trypanosoma brucei

Protein prenylation occurs in the protozoan that causes African sleeping sickness (Trypanosoma brucei), and the protein farnesyltransferase appears to be a good target for developing drugs. We have cloned the α- and β-subunits of T. brucei protein farnesyltransferase (TB-PFT) using nucleic acid prob...

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Detalhes bibliográficos
Main Authors: Buckner, Frederick S., Yokoyama, Kohei, Nguyen, Lisa, Grewal, Anita, Erdjument-Bromage, Hediye, Tempst, Paul, Strickland, Corey L., Xiao, Li, Van Voorhis, Wesley C., Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913713/
https://ncbi.nlm.nih.gov/pubmed/10749864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M000975200
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