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Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs
[Image: see text] The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913306/ https://ncbi.nlm.nih.gov/pubmed/20401403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c001307b |
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