Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

[Image: see text] The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.

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Hlavní autoři: Burai, Ritwik, Ramesh, Chinnasamy, Shorty, Marvin, Curpan, Ramona, Bologa, Cristian, Sklar, Larry A., Oprea, Tudor, Prossnitz, Eric R., Arterburn, Jeffrey B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913306/
https://ncbi.nlm.nih.gov/pubmed/20401403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c001307b
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