Identification of a GPER/GPR30 Antagonist with Improved Estrogen Receptor Counterselectivity

GPER/GPR30 is a seven-transmembrane G protein-coupled estrogen receptor that regulates many aspects of mammalian biology and physiology. We have previously described both a GPER-selective agonist G-1 and antagonist G15 based on a tetrahydro-3H-cyclopenta[c]quinoline scaffold. The antagonist lacks an...

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Main Authors: Dennis, Megan K., Field, Angela S., Burai, Ritwik, Ramesh, Chinnasamy, Petrie, Whitney K., Bologa, Cristian G., Oprea, Tudor I., Yamaguchi, Yuri, Hayashi, Shin-ichi, Sklar, S. Larry A., Hathaway, Helen J., Arterburn, Jeffrey B., Prossnitz, Eric R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220788/
https://ncbi.nlm.nih.gov/pubmed/21782022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2011.07.002
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