GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA

AID (activation-induced cytidine deaminase) catalyzes transcription-dependent deamination of C → U in immunoglobulin variable (IgV) regions to initiate somatic hypermutation (SHM) in germinal center B-cells. SHM is essential in generating high affinity antibodies. Here we show that when coexpressed...

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Bibliografiske detaljer
Main Authors: Maeda, Kazuhiko, Singh, Shailendra Kumar, Eda, Kazufumi, Kitabatake, Masahiro, Pham, Phuong, Goodman, Myron F., Sakaguchi, Nobuo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911284/
https://ncbi.nlm.nih.gov/pubmed/20507984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131441
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