Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification

Activation-induced deoxycytidine deaminase (AID) initiates somatic hypermutation (SHM) and class-switch recombination (CSR) by deaminating C→U during transcription of Ig-variable (V) and Ig-switch (S) region DNA, which is essential to produce high-affinity antibodies. Here we report the crystal stru...

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Dettagli Bibliografici
Pubblicato in:DNA Repair (Amst)
Autori principali: Pham, Phuong, Afif, Samir A., Shimoda, Mayuko, Maeda, Kazuhiko, Sakaguchi, Nobuo, Pedersen, Lars C., Goodman, Myron F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917410/
https://ncbi.nlm.nih.gov/pubmed/27258794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.05.029
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