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GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA
AID (activation-induced cytidine deaminase) catalyzes transcription-dependent deamination of C → U in immunoglobulin variable (IgV) regions to initiate somatic hypermutation (SHM) in germinal center B-cells. SHM is essential in generating high affinity antibodies. Here we show that when coexpressed...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911284/ https://ncbi.nlm.nih.gov/pubmed/20507984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131441 |
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