Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells

Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision...

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Udgivet i:Int Immunol
Main Authors: Eid, Mohammed Mansour Abbas, Shimoda, Mayuko, Singh, Shailendra Kumar, Almofty, Sarah Ameen, Pham, Phuong, Goodman, Myron F., Maeda, Kazuhiko, Sakaguchi, Nobuo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Original Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890899/
https://ncbi.nlm.nih.gov/pubmed/28541550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxx032
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