GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity

The single-stranded DNA-dependent deoxycytidine deaminase APOBEC3G (A3G) is a potent restrictive factor against HIV-1 virus lacking viral-encoded infectivity factor (Vif) in CD4(+) T cells. A3G antiretroviral activity requires its encapsulation into HIV-1 virions. Here we show that germinal center-a...

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Main Authors: Maeda, Kazuhiko, Almofty, Sarah Ameen, Singh, Shailendra Kumar, Eid, Mohammed Mansour Abbas, Shimoda, Mayuko, Ikeda, Terumasa, Koito, Atsushi, Pham, Phuong, Goodman, Myron F., Sakaguchi, Nobuo
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086635/
https://ncbi.nlm.nih.gov/pubmed/24198285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302057
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